Piperine

Application
Piperine may be used as an analytical reference standard for the quantification of the analyte in:
Human plasma using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).[1] Piper nigrum extract using reversed phase high pressure liquid chromatographic method with UV detection (RP-HPLC-UV).[2] Food products using high-performance liquid chromatography with diode array detection (HPLC-DAD).[3]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Piperine is a naturally occurring bioactive alkaloid in pepper, which imparts pungency and bitter flavor to it.[4] It has demonstrated health benefits and exhibits therapeutic properties,[4] which include its role as an antimicrobial, antioxidant, antifungal,[5] immunomodulatory[4] and hepatoprotective agent.[5] The inhibition of drug-metabolizing enzymes in hepatic and pulmonary tissues, and the enhancement of drug bioavailability by this compound are reported.[5] It is also found to play an important role in reducing blood glucose, cholesterol and triglycerides.[4] Piperine is an amide isolated from the plant, Piper longum.[6] It is a known inhibitor of hepatic and intestinal glucuronidation.[7] Piperine is found to exhibit pharmacological properties like antitumor, antipyretic and anti-inflammatory activities.[6]