Rotenone

Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Rotenone may be used as an analytical reference standard for the quantification of the analyte in raw honey samples[1] and biological samples[2] using different chromatography techniques.
Biochem/physiol Actions
Inhibitor of mitochondrial electron transport.
Rotenone is an inhibitor of mitochondrial electron transport at nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone acts as a neurotoxic agent which can produce Parkinson-like condition to serve as an animal model for the study of etiology and interventions. The primary mechanism of action of rotenone is complex I inhibition, followed by the generation of oxidative stress and oxidative damage. Because rotenone is lipophilic, it readily penetrates the brain, where it attaches to and inhibits mitochondrial complex I of electron chain transport (ETC).
General description
Rotenone is a contact insecticide and a slow stomach poison, extremely potent against many insects.[3] It is widely used against Varroa Jacobsoni mite, affecting colonies of honey bees.[1] Other Notes
2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Legal Information
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany