Application
α-Ketoglutaric acid may be used as an analytical reference standard for the quantification of the analyte in the following:
Human plasma samples using gas-chromatography coupled to mass spectrometry.[1]
Beer samples using high-performance liquid chromatography with UV detection, and further confirmed by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).[2]
Fruits and vegetables using HPLC-MS/MS.[3]
General description
α-Ketoglutaric acid, an α-ketoacid, is identified as a potential, renal cell carcinoma (RCC) biomarker via urinary metabolomic profiling.[4] It plays an important role in living beings as an angiogenesis suppressor.[1]

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