4,4′-Diaminodiphenylmethane

Application
4,4′-Diaminodiphenylmethane is used as an analytical reference standard for the quantification of the analyte in the following:
Urine samples using gas-chromatography coupled to mass spectrometry (GC-MS).[1] Hepatic microsomal incubation mixture from rabbits using high-performance liquid chromatography-plasma spray mass spectrometry (HPLC-PSP-MS), offline HPLC with fast atom bombardment mass spectrometry (FAB-MS) and fast atom bombardment tandem mass spectrometry (FAB-MS/MS).[2]

It is reported to be used in the synthesis of amino modified multi-walled carbon nanotubes/polydimethylsiloxane, which serves as a coating for the stir bar sorptive extraction (SBSE) of phenols in environmental samples, followed by analysis using high performance liquid chromatography with ultraviolet detection (HPLC-UV).[3] Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
4,4′-Diaminodiphenylmethane (MDA) is an aromatic diamine, which finds industrial applications as a precursor in the manufacturing of polyurethane products,[4] isocyanates, polyisocyanates, etc. It is also used as a hardener in the production of epoxy resins and elastomers.[2] 4,4′-Diaminodiphenylmethane is a curing agent for epoxy resins. It is prepared from formaldehyde aniline when heated with aniline hydrochloride and aniline.[5] This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)