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General description
Fibronectin is a ubiquitous protein of the extracellular matrix. It is a mosaic protein, that is made up of three types of repeating modular consensus amino acid sequences.[1] Fibronectins belongs to a class of high-molecular-weight glycoproteins.[2] Cellular fibronectin is expressed by fibroblasts and plasma fibronectin is usually liberated by hepatocytes.[1]
Application
Fibronectin (FN) bovine plasma has been used in:
fibronectin and adsorption analysis (ELISA (enzyme-linked immunosorbent assay))[3]
transwell migration[4]
fibronectin assay[5]
Biochem/physiol Actions
Fibronectins participate in cell adhesion, cytoskeletal organization, oncogenic transformation, cell migration, phagocytosis, hemostasis, and embryonic differentiation.[2]
Analysis Note
Protein homogeneity is evaluated by immunoelectrophoresis.
Other Notes
Product F1141, Fibronectin from bovine plasma is a solution in 0.05 M TBS pH 7.5.
