IL-4 human

General description
Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor.[1] The gene encoding this protein is localized on human chromosome 5q31.1.[2] Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Biochem/physiol Actions
Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells.[3] The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens.[1] Physical form
Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.