Tiếng ViệtApplication
(2-Hydroxypropyl)-γ-cyclodextrin has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CCs) from plasma samples.[1]
Biochem/physiol Actions
(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble[2] alkylated cyclodextrin derivative.[3] It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations.[2] It solubilizes macromolecules, such as cholesterol.[4] It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis.[4] In the Niemann pick disease model, HPγCD reduces cholesterol accumulation.[4]
Other Notes
Non-toxic solubilizer. γ-Cyclodextrin (8-glucose units) has a slightly larger cavity and can accommodate larger substrates than β-cyclodextrin.
(2-Hydroxypropyl)-γ-cyclodextrin
solid
Code: H1255 g H125-5G-I
100 g H125-100G-I
- Manufacturer: Merck
- Trademark: Sigma-Aldrich
- Hãng sản xuất: Merck
| Hãng sản xuất |
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