DL-4-Hydroxy-2-ketoglutaric acid lithium salt

analytical standard
Code: 61076

Manufacturer: Merck
Trademark: Supelco

Hãng sản xuất: Merck

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Category: Standard Chemical Brand: Supelco

Description
Additional information

General description
DL-4-Hydroxy-2-ketoglutaric acid lithium salt (HOG) is a precursor substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA1), a unique enzyme in the hydroxyproline catabolism pathway. It is reported that the primary hyperoxaluria type 3, which is a recently discovered form of the autosomal recessive disease, results from the mutations in the gene coding for HOGA1.[1] Application
DL-4-Hydroxy-2-ketoglutaric acid lithium salt may be used as an analytical reference standard for the determination of the analyte in animal biological samples using ion chromatography coupled to negative electrospray mass spectrometry (IC/ES-MS). This can be used to determine the primary hyperoxalurias PH Type 3 (PH3), caused by the mutations in the mitochondrial enzyme, 4-hydroxy-2-oxoglutarate aldolase (HOGA).[1]

Hãng sản xuất	Merck

DL-4-Hydroxy-2-ketoglutaric acid lithium salt

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