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General description
This certified solution standard is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS testing applications from forensic analysis and clinical toxicology to urine drug testing.
Ketamine is a phencyclidine type of anaesthetic drug that blocks the N-methyl-d-aspartate (NMDA) receptors present on neurons. It is also an abused drug owing to its euphoric and hallucinogenic effects. The drug is also abused at clubs, raves, or parties for its noted hallucinogenic and dissociative properties and is prescribed by some doctors as an off-label treatment for depression.
Application
The certified reference solution (CRM) in solution can also be used as follows:
Development of a chiral liquid chromatography-tandem mass spectrometric (LC-MS/MS) method to quantify enantiomers of ketamine and norketamine in plasma, brain, and cerebrospinal fluid samples obtained from mouse
Multi-residue and non-destructive analysis of ketamine, methamphetamine, heroin, and cocaine by a near-infrared spectroscopic (NIR) method in seized drug samples
Combined detection and estimation of ketamine, free methamphetamine, pethidine, and tramadol in human urine samples using dispersive liquid-liquid microextraction (DLLME) and gas chromatography-mass spectrometry (GC-MS)
Electrochemical determination of ketamine in human urine samples using a metal-organic framework/graphene nanocomposite (MOFs@G) modified screen-printed electrode (SPE) after the UV polymerization of molecularly imprinted membranes on its surface[1]
Simultaneous analysis of ketamine, GHB, norketamine, phenobarbital, thiopental, zolpidem, zopiclone, and phenytoin in human urine samples by a LC-MS/MS procedure following a four-step liquid-liquid extraction of the samples
Features and Benefits
Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
Rigorously tested through real-time stability studies to ensure accuracy and shelf life
Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
Flame sealed under argon into ampoules for long-term shelf life
Offered in a convenient, DEA-exempt format to improve laboratory efficiency
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
