Methyl methanesulfonate

Application
Methyl methanesulfonate may be used as certified reference material for the quantification of the analyte in pharmaceutical formulations using gas chromatography coupled to triple quadrupole mass spectrometry.[1] Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
DNA adduct; adds methyl groups to DNA at 7-guanine preferentially, but also 3-adenine and 3-guanine.
General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.

Methyl methanesulfonate belongs to the group of alkyl sulfonate esters, termed as potential genotoxic impurities (GTIs).[1] Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany