Withanolide A

Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Withanolide A may be used as an analytical standard for the determination of withanolide A in:
Mentat tablet, an Indian herbal medicine by UHPLC coupled to tandem mass spectrometry (MS/MS) operating with ESI, along with multivariate analysis.[1] Withania somnifera by ultra-high performance liquid chromatography-hybrid triple quadrupole linear ion trap mass spectrometer (UHPLC-QqQ LIT-MS) equipped with electrospray ionization (ESI) source and MRM detection, along with multivariate analysis[2] as well as HPLC combined with diode array detector (DAD).[3] Withania coagulans by LC-QqQ-ESI-MS/MS.[4]

Biochem/physiol Actions
C28-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer′s and Parkinson′s disease. In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.
General description
Withanolide A is classified under the steroidal lactone group of bioactive compounds that are majorly found in Withania somnifera (L.).[5] Other Notes
This compound is commonly found in plants of the genus: lycium withania
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.