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1) Description
PVDF syringe filters are available in both hydrophilic and hydrophobic membrane types, suitable for aqueous, organic and mixed solvent filtration.
Hydrophilic PVDF offers excellent water wettability, low protein binding and low UV-absorbing extractables, making it ideal for biological samples and polymers.
Hydrophobic PVDF provides strong chemical resistance and stable flow for organic solvents, alcohols and aerosol/gas filtration.
Designed for filtration of water-soluble oligomers and polymers, protein-containing solutions, and samples requiring high protein recovery.
Available pore sizes: 0.22 μm / 0.45 μm
Available diameters: 13 mm / 25 mm / 33 mm
2)Features
▶ Low protein binding, suitable for proteins, peptides and biological macromolecules
▶ Hydrophilic PVDF: excellent aqueous wettability and fast flow
▶ Hydrophobic PVDF: high flow rate and strong chemical/temperature resistance
▶ Low UV-absorbing extractables, ensuring analytical accuracy in HPLC/UV applications
▶ Stable mechanical strength with large effective filtration area
▶ Prevents solvent leakage and maintains consistent flow across the membrane
▶ Superior performance for both aqueous and organic solvent filtration
3) Application
◆ Sterilizing and clarifying biological solutions
◆ Filtration of protein samples, culture media, buffers and mild organic solutions
◆ Gas and vapor filtration (hydrophobic PVDF)
◆ High-temperature and industrial chemical filtration
◆ Suitable for food, medicine, and environmental sample preparation
◆ Compatible with aggressive acids, alcohols and organic solvents
◆ Ideal when high protein recovery or low nonspecific adsorption is required
4) How to choose filter size?
0–1 mL → 4 mm syringe filters (hold-up volume < 10 μL)
0–10 mL → 13 mm syringe filters (hold-up volume < 25 μL)
10–100 mL → 25 mm syringe filters (hold-up volume < 100 μL)
10–150 mL → 33 mm syringe filters (hold-up volume < 125 μL)
5) FAQ
Q1: What is the difference between hydrophilic and hydrophobic PVDF?
- Hydrophilic PVDF: excellent aqueous wettability, low protein binding, ideal for biological samples and buffers.
- Hydrophobic PVDF: suitable for organic solvents, alcohols, air/gas filtration, and aerosol sampling.
Q2: Is PVDF suitable for filtering protein samples?
Yes. PVDF membranes have low protein binding, making them suitable for proteins, peptides and biological macromolecules.
For maximum protein recovery, hydrophilic PVDF is recommended.
Q3: Can PVDF syringe filters be used with aggressive chemicals?
Yes. PVDF has excellent chemical resistance to many acids, alcohols, esters, and organic solvents.
For extremely harsh or corrosive solvents, PTFE may still be preferred.
Q4: Are PVDF filters compatible with HPLC/UV analysis?
Yes. PVDF membranes have low UV-absorbing extractables, ensuring reliable baseline stability for HPLC-UV or LC analysis.
Q5: Can PVDF be used for sterilizing filtration?
Hydrophilic PVDF is suitable for sterilizing or clarifying biological solutions, including buffers, enzymes and serum-free media.
However, check pore size (0.22 μm recommended for sterilization).
Q6: Is hydrophobic PVDF suitable for gas or vent filtration?
Absolutely. Hydrophobic PVDF provides excellent air flow, chemical resistance and high loading capacity, making it suitable for gas or aerosol applications.
Q7: Is PVDF temperature-resistant?
Yes. PVDF membranes have excellent temperature stability, allowing extended sampling ranges compared to many other membrane materials.
Q8: What pore size should I choose for PVDF syringe filters?
- 0.22 μm → sterilization, fine particulate removal, biological samples
- 0.45 μm → routine clarification, solutions with moderate load
Choose based on sample viscosity and the level of clarity required.
