English
General description
Glucagon is a peptide hormone of 29 amino acids secreted by alpha cells in the pancreas. Its release is controlled by hypothalamus when glucose levels in the blood decreases.[1] The C-terminal region of glucagon is crucial for receptor binding.[2]
Application
Glucagon has been used:
in the stimulation of human primary hepatocytes for cyclic adenosine monophosphate (cAMP) production[3]
for measuring glucagon response in mice[4]
to induce gluconeogenic stimuli in primary hepatocytes[5]
Biochem/physiol Actions
Glucagon functions to elevate glucose by activating GCGR in liver mediating the glucose circulation in blood.[6] The hyperglucagonemia elevated levels of glucagon is observed in diabetes[1] and in nonalcoholic fatty liver disease, post gastric bypass surgery and glucagon based tumors.[7]
Physical form
powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
Other Notes
H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl
This product is a chemically synthesized glucagon qualified for use in cell culture applications.
