English
General description
LiChrospher® RP-8 is a reliable and versatile traditionally produced spherical silica gel carrier with C-8 reversed phase properties. It is well suited for the separation of neutral, acidic and weak basic compounds.
Application
Development and validation of a HPLC-UV method for the determination in didanosine tablets.: This study presents a validated HPLC-UV method optimized using LiChrospher® 100 RP-8 (5 µm) for analyzing didanosine in tablet formulations, offering a reliable tool for quality control in pharmaceutical environments (de Oliveira et al., 2005).
Determination of steroid hormones in oral contraceptives by high-performance liquid chromatography.: Utilizes LiChrospher® 100 RP-8 (5 µm) to effectively separate and quantify steroid hormones in oral contraceptive pills, demonstrating the column′s applicability in complex pharmaceutical analyses (Inês et al., 2002).
Determination of fluoroquinolone residues in animal tissues by liquid chromatography.: Explores the use of LiChrospher® 100 RP-8 (5 µm) for the sensitive detection of fluoroquinolone residues in animal tissues, highlighting its potential for food safety and veterinary medicine applications (Posyniak et al., 1999).
Rapid and simple determination of oxytetracycline in chicken products.: Demonstrates the column′s efficiency in rapidly quantifying oxytetracycline residues in chicken, ensuring compliance with food safety standards (Furusawa, 1999).
Crocheted ETFE-reactor for on-line post-column photoderivatization of diclofenac in high-performance liquid chromatography.: Describes an innovative application involving LiChrospher® 100 RP-8 (5 µm) in a post-column reactor setup to enhance the detection sensitivity of diclofenac, underlining the column′s versatility in advanced analytical techniques (Kuhlmann et al., 1997).
Analysis Note
Application test: passes test
Pressure: ≤ 45 bar
Theoretical Plates (N/m) (Toluene): ≥ 60000
Capacity factor (Toluene): ≥ 0.7
stability testing (performance): passes test
separation factor (PTH-Lysine/PHB-Propyl-Ester, selectivity test): 1.20 – 1.55
separation factor (Naphthalene/Digitoxigenin, selectivity test): 3.5 – 4.7
separation factor (PTH-Lysine/Digitoxigenin, selsctivity test): 1.70 – 2.25
Particle Size (d10): 4.8 – 5.5 µm
Particle Size (d50): 6.5 – 7.5 µm
Particle Size (d90): 9.0 – 10.5 µm
Legal Information
LiChrospher is a registered trademark of Merck KGaA, Darmstadt, Germany
