EnglishBiochem/physiol Actions
Heparin-binding epidermal growth factor (HB-EGF), like BTC, is a heparin-binding EGF family member. Natural soluble HB-EGF is a 19 kDa glycoprotein of multiple forms due to heterogeneous truncations. Soluble HB-EGF is mitogenic and chemotactic for fibroblasts, keratinocytes, and smooth muscle cells but not capillary endothelial cells. Production of HB-EGF is detected in monocytes, macrophages, and vascular and aortic smooth muscle cells (SMC). HB-EGF may play a role in the pathogenesis of atherosclerosis. It may also be an effector of Jun-induced oncogenic transformation. HB-EGF binds to EGFR with high affinity and to ErbB with moderate affinity.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the EGF-responsive BALB/3T3 cells.
Heparin-Binding EGF-Like Growth Factor human
≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Code: E4643
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
- Hãng sản xuất: Merck
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Sản phẩm tương tự
Fetal Bovine Serum
USA origin, sterile-filtered, suitable for cell culture, suitable for hybridoma
Code: F2442
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
RPMI-1640 Medium
With ʟ-glutamine, sodium bicarbonate, liquid, sterile-filtered, suitable for cell culture
Code: R8758100 mL R8758-100ML
500 mL R8758-500ML
1 L R8758-1L
6 x 500 mL R8758-6X500ML
6 x 1 L R8758-6X1L
24 x 500 mL R8758-24X500ML
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Mouse Laminin
from Engelbreth-Holm-Swarm murine sarcoma basement membrane, 0.2 μm filtered, liquid, 1-2 mg/mL, suitable for cell culture
Code: L2020
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Human Serum
from human male AB plasma, USA origin, sterile-filtered
Code: H4522
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Poly-ʟ-Ornithine
synthetic, mol wt 30,000-70,000, liquid, 0.01%, suitable for cell culture
Code: P4957
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Fetal Bovine Serum
USA origin, Heat Inactivated, sterile-filtered, suitable for cell culture, suitable for insect cell culture, suitable for hybridoma
Code: F4135
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Bovine Serum Albumin
lyophilized powder, ≥96% (agarose gel electrophoresis)
Code: A2153
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Accutase® solution
sterile-filtered, suitable for cell culture
Code: A6964
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Bovine Fibronectin
from bovine plasma, liquid, suitable for cell culture
Code: F1141
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Dimethyl sulfoxide
Hybri-Max™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%
Code: D2650
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
