Alpha 2 Macroglobulin from human plasma

General description
α 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg/100 mL in men and 290 mg/100 mL in women. It is produced by the liver, and is a major component of the α-2 band in protein electrophoresis.[1] It has a molecular weight of 800,000 Da.[2] Biochem/physiol Actions
α 2 macroglobulin (A2M) functions as a broad-spectrum protease-binding protein. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to α 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer′s disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble β-amyloid, of which it mediates degradation.[1][2] Clinically, levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.
Physical form
Lyophilized from 30 mM Na Phosphate, pH 7.0, with glycine as a stabilizer.
Preparation Note
In water or aqueous buffer