English
General description
Interleukin-1α (IL-1α) is a cytokine that belongs to the interleukin-1 (IL-1) family.[1] It is located intracellularly in hematopoietic and non-hematopoietic cells.[2] IL-1α gene is located on the human chromosome at 2q14.1.[3]
Application
Interleukin-1α (IL-1α) has been used:
to study its effects on human colorectal adenocarcinoma cells[4]
to stimulate primary human fetal retinal pigment epithelium (hfRPE) cells[5]
to pre-stimulate human THP-1 monocytes[6]
Biochem/physiol Actions
Interleukin-1α (IL-1α) plays a crucial role in inflammation during cell necrosis. It also regulates the recruitment of interleukin-1β (IL-1β), neutrophils, chemokines, and other cytokines at the site of injury. IL-1α exhibits a dual function of binding to its cell surface receptor as well as chromatin.[1]
Physical form
Lyophilized from 0.2 μm filtered 10 mM sodium phosphate , pH 8.0, plus 50 mm NaCl and 50 μg bovine serum albumin (BSA) per μg cytokine.
Analysis Note
The proliferative activity of human IL-1α is tested in culture using the murine cell line D10S.
