Adrenocorticotropic Hormone Fragment 1-24 human, rat

General description
Adrenocorticotropic hormone (ACTH), also called proopiomelanocortin (POMC), is a 303-amino acid hormone protein. Proteolysis of ACTH results in active peptides.[1] ACTH is mapped to human chromosome 2p23.3.[2] The portion of the ACTH sequence that is conserved across species; has ~75% of the potency of ACTH on a molar basis.
Application
Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay[3] and to induce color change in frogs.[4] Biochem/physiol Actions
Activates G proteins.
Adrenocorticotropic hormone (ACTH) activates melanocortin receptor (MC1R to MC5R) and plays a key role in generation of α-melanocyte-stimulating hormone (α-MSH).[1] The loss of function mutations in ACTH gene is implicated in obesity and red hair.[2] Hypomethylation of POMC promoter region in thymic carcinoids is associated with ectopic adrenocorticotropic hormone syndrome.[5] POMC mutation results in generation of abnormal fusion protein, impairing melanocortin signalling in hypoadrenalism.[6] Dysregulation of ACTH gene transcription impacts metabolic pathways leading to Cushing disease.[7] Other Notes
Lyophilized from 0.1% TFA in H2O