Nerve Growth Factor β Human

General description
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.[1] Application
NGF-β human has been used:
in protein pin arrays[2] to induce U87-MG (glioblastoma cell line) cell proliferation[3] in drug release kinetics[4]

Biochem/physiol Actions
Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation,[1][5] and survival.[5] Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms.[1] NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis.[6][7] It facilitates the development of various cancer including, oral,[7] breast, lungs, pancreatic and prostate cancers.[6][7] Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma.[7] In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory.[8] NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
Physical form
Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
Analysis Note
The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.