English
General description
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Rat astrocytes (RA) are derived from rat cerebral cortex. Astrocytes are the most abundant cells in the central nervous system where they perform many functions, such as providing mechanical support and nutrients to neurons and removal of wastes from neurons; providing signaling to endothelial cells; regulating neurogenesis and controlling synaptic function. As the recognition of the importance of astrocytes in nervous system is increasing, RA serve as a useful in vitro model for exploring the diversity of astrocytes functions.Characterization: Stained positive for GFAP.Rat Astrocytes (RA) and Rat Brain Microvascular Endothelial Cells (RBMEC), both from Cell Applications, Inc., have been used to assess neuroprotective capabilities of bioenergy stabilizers in an in vitro model of stroke (Liu, 2013) and to investigates the effects of astrocytes on brain microvascular endothelial cells in relation to iron transport pathway (McCarthy, 2014).
Application
Neuroscience research, mechanical & biochemical support, ion balance, nutrient provision, waste removal, cell signaling, regulation of neurogenesis, control of synaptic function, astrocyte function, gene expressino, injury repair, gliotransmitter release, neuronal excitability.
Biochem/physiol Actions
Brain
Preparation Note
2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
Can be cultured at least 10 doublings
Analysis Note
Each lot was tested for proper morphology, Population Doublings, Negative for HIV, Hepatitis B, Hepatitis C, mycoplasma, bacteria, and fungi.
Other Notes
Basal Medium containing 10% FBS & 10% DMSO
