EnglishGeneral description
The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3.[1]
Application
VEGF-C human has been used to determine cell proliferation and survival.[2]
Biochem/physiol Actions
VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis.[3] The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis.[4] Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.[5]
Physical form
Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.
VEGF-C human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Code: SRP4633
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
- Hãng sản xuất: Merck
| Hãng sản xuất |
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Sản phẩm tương tự
Bovine Serum Albumin
lyophilized powder, ≥96% (agarose gel electrophoresis)
Code: A2153
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Poly-ʟ-Ornithine
synthetic, mol wt 30,000-70,000, liquid, 0.01%, suitable for cell culture
Code: P4957
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Dimethyl sulfoxide
sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma
Code: D2438
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Bovine Fibronectin
from bovine plasma, liquid, suitable for cell culture
Code: F1141
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Mouse Laminin
from Engelbreth-Holm-Swarm murine sarcoma basement membrane, 0.2 μm filtered, liquid, 1-2 mg/mL, suitable for cell culture
Code: L2020
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Accutase® solution
sterile-filtered, suitable for cell culture
Code: A6964
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Poly-ʟ-Lysine Hydrobromide
synthetic, liquid, 0.01%, suitable for cell culture
Code: P4707
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Insulin solution human
sterile-filtered, BioXtra, suitable for cell culture
Code: I9278
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Fetal Bovine Serum
USDA approved, sterile-filtered, suitable for cell culture
Code: F0926
- Hãng sản xuất: Merck
- Thương hiệu: Sigma-Aldrich
Millipore® Stericup® Quick Release Vacuum Filtration System
pore size 0.22 μm, polyethersulfone membrane, filter capacity 1000 mL, pack of 12 ea
Code: S2GPU11RE
- Hãng sản xuất: Merck
- Thương hiệu: Millipore
