γ-Butyrolactone

Biochem/physiol Actions
Precursor of γ-hydroxybutyric acid (GHB); blocks dopamine release.
Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release.
Application
γ-Butyrolactone may be used as an analytical reference standard for the quantification of the analyte in roasted Italian chestnuts,[1] wine samples,[2] beverages[3] using chromatography techniques.
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General description
γ-Butyrolactone (GBL) is a related lactone analog of γ-hydroxybutyric acid (GHB), a widespread drug of abuse, identified as an endogenous constituent of the mammalian brain, in which it exhibits a strong central nervous system depressant effect.[1][4] GBL is considered as a legal substitute of GHB,[5] and commonly identified in beverages including coffee,[6] apple cider vinegar, tea, carbonated drinks, etc.[3]