Albumin, Nitrated from bovine serum

General description
Albumin, Nitrated (Nitrated BSA), is prepared by chemical modification of bovine serum albumin (BSA) by peroxynitrite. Peroxynitrite (ONOO-), a potent oxidant is an important member of the family of reactive oxygen and nitrogen species.[1] Application
Positive control in immunoblotting assays for Anti-Nitrotyrosine[2] (Sigma Product Number N 0409).
Biochem/physiol Actions
Peroxynitrite promotes the nitration of tyrosine residues in proteins linked, oxidation of redox metal centers, DNA, lipids and nitrosation of cysteine residues in proteins, suggesting that peroxynitrite plays a major role in oxidative cellular damage.[1] Peroxynitrite has been implicated in the pathogenesis of several inflammatory, infectious and degenerative human disease. These include neurological conditions such as Alzheimer′s disease, amyotrophic lateral sclerosis (ALS), the pathogenesis of asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury.[3] Physical form
Lyophilized from 0.01 M phosphate buffered saline, pH 7.4
Preparation Note
Bovine serum albumin (BSA) nitrated with peroxynitrite.
Analysis Note
Does not contain sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.