English
General description
L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.
Application
D-Valine has been used as a supplement in:
Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture[1]
endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture[2]
DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture[3]
Biochem/physiol Actions
D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.[4]
D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.
