English
Application
Dexamethasone-Water Soluble has been used as a component of
Dulbecco′s modified Eagle medium based osteogenic and adipogenic medium for human mesenchymal stem cell culture[1]
erythroid expansion media for the growth of liver, bone marrow and spleen tissues[2]
medium 199 (M199) for hepatocyte culture[3]
Biochem/physiol Actions
Dexamethasone is an anti-inflammatory glucocorticoid[4] and a synthetic corticosteroid used for treating corneal inflammation. It inhibits the IL-1β-dependent angiogenesis.[5] Dexamethasone elicits a range of effects on cell survival, cell signaling and gene expression.[6] It favors apoptosis in chondrocytes and impairs development of bone.[7] Dexamethasone is a potential therapeutic agent as it induces apoptosis in multiple myeloma (MM) cells.[8] It elicits its functionality by lowering glucocorticoid receptor (GR) α levels and inhibits colon tumor progression.[9]
Packaging
Package size based on dexamethasone
Other Notes
Contains approx. 65 mg dexamethasone per gram; balance methyl-β-cyclodextrin.
