Fibroblast Growth Factor-4 human

General description
Fibroblast Growth Factor-4 (FGF4) is a 19 kDa protein, belonging to the FGF family of proteins.[1] Fibroblast growth factors (FGF) are glycoproteins concealed in the extracellular matrix and cell surface.[2] There are around 22 different types of FGFs known. These factors weigh in the range of 17 to 34 kDa and they possess a conserved sequence of 120 amino acids.[3] The FGF4 gene is mapped to human chromosome 11q13.3.[4] Application
Fibroblast Growth Factor-4 human has been used:
To maintain trophectoderm stem cells.[5] In neurogenic differentiation.[6] In hepatocyte differentiation.[7]

Biochem/physiol Actions
Fibroblast growth factor-4 (FGF-4) is a 19 kDa protein identified in NIH-3T3 cell assays as a transforming gene from DNA derived from human tumors, including stomach (hst) and colon cancers, Kaposi′s sarcoma, and hepatocellular carcinoma. FGF-4 includes a secretory signal sequence and shares 42% sequence identity with FGF-Basic at the amino acid level. Both FGF-4 and FGF-Basic bind to the same receptors. Mouse and human FGF-4 shares 82% homology with species cross-reactivity. FGF-4 does not appear to be expressed in normal adult tissues, but during embryogenesis, the gene is spatially and temporally regulated. FGF-4 is a mitogen for fibroblasts and endothelial cells and a potent promoter of angiogenesis. It is believed to be critical in embryonic limb development.
Fibroblast growth factor-4 (FGF-4) is identified in NIH-3T3 cell assays as a transforming gene from DNA derived from human tumors, including stomach (hst) and colon cancers, Kaposi′s sarcoma, and hepatocellular carcinoma. FGF-4 includes a secretory signal sequence and shares 42% sequence identity with FGF-Basic at the amino acid level. Both FGF-4 and FGF-Basic bind to the same receptors. Mouse and human FGF-4 shares 82% homology with species cross-reactivity. FGF-4 does not appear to be expressed in normal adult tissues, but during embryogenesis, the gene is spatially and temporally regulated. FGF-4 is a mitogen for fibroblasts and endothelial cells and a potent promoter of angiogenesis. It is believed to be critical in embryonic limb development. FGF-4 participates in cell differentiation and cell migration.[1] Physical form
Lyophilized from a 0.2 µm filtered solution containing 20 mM Sodium Phosphate, 0.5 M Sodium Chloride, pH 7.5
Preparation Note
Reconstitution: Sterile water at 0.1 mg/mL
Analysis Note
The biological activity is measured by its ability to stimulate NR6R-3T3 cell proliferation.