English
General description
Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland.[1] FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.[2]
Research area: Cell Signaling
Biochem/physiol Actions
Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals.[2] It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR)[2] that is located on the granulosa cells of the ovaries and Sertoli cells of the testes.[1] FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males.[2] The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.[3]
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
Costrici, N., et al. 1995. Endocrinology136, 4705.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
