English
Application
Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:
Pharmaceutical formulations using reversed-phase high-performance liquid chromatography[1][2][3] and UV-spectrophotometric techniques.[2]
Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.[4]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.
orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist
General description
Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.[5]
Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.[6]
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
