English
General description
β-Estradiol 6-(O-carboxymethyl)oxime: BSA is an estradiol conjugate and is membrane-impermeable.[1] BSA is linked to the estradiol at position 6 to form the β-estradiol 6-(O-carboxymethyl) oxime: BSA conjugate.[1]
Application
β-Estradiol 6-(O-carboxymethyl)oxime: BSA has been used:
to test its effect on the N-methyl-D-aspartate receptor (NMDAR) currents in female dorsal root ganglion (DRG) neurons[2]
to coat microplates for the detection of plasma 17β-Estradiol levels using indirect enzyme-linked immunosorbent assay (ELISA)[3]
to test its effect on MutL homolog 1 in colorectal cancer lines[4]
Biochem/physiol Actions
β-Estradiol 6-(O-carboxymethyl)oxime: BSA mimics estrogen and favors amyloid precursor protein α (sAPPα) secretion in vitro studies with primary rat cortical neurons.[1] It also stimulates mitogen-activated protein kinase (MAPK) activity in human umbilical vein endothelial cells [5]
