English
General description
Human serum albumin (HSA) is an abundant protein found in the plasma.[1] This globular, soluble, and unglycosylated monomeric protein[2], has three homologous domains (I, II, and III).[1][3] These domains have subdomains A and B having common structural motifs. The HSA gene is located on the human chromosome 4q13.3.[3]
Application
Albumin, Human Serum, Fraction V, Low Heavy Metals has been used:
as a supplement in double buffer and milliQ-water for in vivo[4]
in serum-free media for polarized secretion assays in human dermal microvascular endothelial cells[5]
as a supplement in sodium phosphate buffer for the reconstitution of hormone lysis samples[6]
Biochem/physiol Actions
Human serum albumin (HSA) is very crucial in stabilizing extracellular fluid volume. It functions as an excipient for vaccines and therapeutic protein drugs. HSA serves as a cell culture medium supplement for the synthesis of vaccines and pharmaceuticals.[2] It is useful as a carrier protein for steroids, fatty acids, and thyroid hormones.[2] HSA is used to treat cardiopulmonary bypass, trauma, hemorrhage, and hypoalbuminemia.[1] HSA is useful in biological applications, such as implantable biomaterials, biochromatography, surgical adhesives, and sealants.[1]
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)
