Albumin, Human Serum, Fraction V

General description
Human serum albumin (HSA), a globular, soluble, and unglycosylated monomeric protein,[1] is the most abundant protein in the plasma.[2] It is a multidomain protein consisting of three homologous domains, named I, II, and III.[2][3] Each of these domains contains subdomains A and B possessing common structural motifs. The HSA gene is present on the human chromosome location 4q13.3.[3] Biochem/physiol Actions
Human serum albumin (HSA) serves as a carrier protein for fatty acids, thyroid hormones, and steroids.[1] It plays a critical role in stabilizing extracellular fluid volume. HSA acts as an excipient for vaccines and therapeutic protein drugs. It is also used as a cell culture medium supplement to produce vaccines and pharmaceuticals.[1] HSA is used to treat hemodialysis, acute liver failure, chronic liver disease.[2] HSA has importance in biological applications, such as ligand trapping, nano delivery of drugs, and fusion proteins.[2][1] Preparation Note
Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Toxicity: Standard Handling (A)