BMP-14 (GDF-5/CDMP-1) human

General description
The gene BMP-14 (bone morphogenetic protein 14) is mapped to human chromosome 20q11.22.[1] It belongs to the bone morphogenetic protein family.[2] Recombinant human BMP-14 is a 27kDa homodimeric protein consisting of two 120 amino acid polypeptide chains.
Biochem/physiol Actions
BMP-14 (bone morphogenetic protein 14) is involved in enhancing proliferations of osteoblasts, periosteum cells and connective tissue fibroblasts. It also promotes endochondral bone growth, proper development of limb skeletons and joints, and odontogenesis. It interacts with BMP type II receptor (BMPR-II) and might be involved in bone morphogenesis.[2] Mutations in the BMP-14 gene are associated with brachydactyly type C, intervertebral disc degeneration, acromesomelic dysplasia Grebe type and osteoarthritis.[3][4][5][1] Physical form
Lyophilized from 10 mM Sodium Citrate, pH 3.5.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute to a concentration of 0.1-1.0 mg/mL in water containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.