Bovine Pulmonary Artery Smooth Muscle Cells: BPASMC (Cryovial)

General description
Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

BPASMC have been used in studies relevant to pulmonary hypertension characterized by hyperproliferation of pulmonary artery smooth muscle cells, the process shown to be mediated by hypoxia-induced expression of Bcl-xl (Suzuki, 2007). Additionally, they were used to elucidate the PKC-α dependent mechanisms of proMMP-2 activation and other signaling events in smooth muscle cells under pro-inflammatory conditions related to cell growth (Chakraborti, 2009; Roy, 2011, 2013; Dey, 2012; Chowdhury, 2013; Shaikh, 2013).

Characterization: positive for smooth muscle cell specific alpha-actin expression.
Application
cell growth, signaling, receptor transactivation and suppression, vascular remodeling
Biochem/physiol Actions
Artery
Preparation Note
2nd passage, >500,000 cells in Bovine Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO
Can be cultured at least 16 doublings
Please refer to the BPASMC Culture Protocol.
Other Notes
Bovine Smooth Muscle Cell Basal Medium containing 10% FBS & 10% DMSO