CellASIC ONIX switching plate mammalian cells (4 chamber)

General description
CellASIC® ONIX switching plate mammalian cells (4 chambers) enable continuous perfusion culture for live cell analysis. Laminar flow provides a rapid and uniform solution exchange for maximum cell health. The glass cover slide bottom surface ensures the highest resolution of optical viewing.
Application
CellASIC® ONIX switching plate mammalian cells(4 chambers) have been used:
in live-cell imaging to study the contribution of phi-particle in the autoinhibition of dynein and the activation of dynein by dynactin[1] in live-cell imaging of fcSAgA binding and immunoglobulin M surface clustering by fluorescence microscopy[2] in multiple epidermal growth factor (EGF)pulse experiments[3] The CellASIC® ONIX switching plate is suitable for use in:
time-lapse analysis of adherent cells
long-term continuous perfusion experiments (3 days typical)
solution exchange experiments (induction, inhibition, drug dosing, etc.)
automated immunostaining and on-demand fixation of live cells within the culture chamber
comparison of up to four different cell types or exposure conditions (media components) in parallel, temperature, and gas atmospheric control (temperature shift, anoxic conditions, etc.)
Features and Benefits
Compatible with CellASIC® ONIX2 Microfluidic system and ONIX2 Manifolds
Enables perfusion-based, long-term, live-cell analysis with solution switching
The plate offers a controlled and dynamic microenvironment for 2D and 3D cell cultures
Legal Information
CELLASIC is a registered trademark of Merck KGaA, Darmstadt, Germany