CTGF human

General description
The gene CTGF (connective tissue growth factor) is mapped to human chromosome 6q23.2.[1] CTGF is a member of the CCN (Cyr61, CTGF , Nov) family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells.[2][3][4] The protein has an N-terminal secretory signal peptide and four domains (an insulin-like growth factor-binding protein domain, a Von Willebrand factor domain, a thrombospondin type-1 repeat module, and a CT).[2] It is expressed in various tissues, such as connective tissue, heart, brain, kidney, lung, liver, muscle, pancreas gland and placenta.[4] Recombinant human CTGF is a 11.2Da protein of 98 amino acid residues.
Biochem/physiol Actions
CTGF (connective tissue growth factor) stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells.[5][6][7] It binds to IGF (insulin growth factor), TGF (transforming growth factor) β1 and BMP (bone morphogenetic protein)-4. CTGF plays a crucial role in the progression of diabetic nephropathy.[3] It can work as an oncoprotein in glioma and melanoma. However, it works as a tumor suppressor in lung cancer and colon cancer.[8] Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.