Ethylenediaminetetraacetic acid disodium salt dihydrate

General description
Ethylenediaminetetraacetic acid (EDTA) is an aminopolycarboxylic acid and a hexadentate ligand. It chelates with metal ions, especially with cations to form an octahedral complex.[1] Ethylenediaminetetraacetic acid disodium salt (EDTA) is a blood anticoagulant and contributes to the pathogenesis of pseudothrombocytopenia. It chelates with calcium in the blood and inhibits clotting and is routinely used in haematological tests.[2] It enhances the antibacterial activity of lysozyme.[3] EDTA used in chelation therapy chelates with calcium and favors dilation of artery, solubilisation of atheromatous plaques in atherosclerotic vascular disease.[4] EDTA chelation therapy may also protect from oxidative damage during blood and lipid peroxidation in liver fibrosis. [5] Application
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
Ethylenediaminetetraacetic acid disodium salt dihydrate has been in seed germination trials of plant species[6] and in protein extraction from Moss, Physcomitrella paten.[7] It has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.[8]