English
General description
Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein.[1][2] It is produced by the liver and adipose tissue.[2]
Application
Fetuin from fetal bovine serum has been used:
to synthesize primary and secondary calciprotein particles (CPP)[3]
to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins[4]
as a supplement in Ham′s F10 media for myoblast culture[5].
Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.
Biochem/physiol Actions
Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism.[6] It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases.[7] Fetuin has anti-inflammatory property.[2]
Preparation Note
Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).
