Insulin-like Growth Factor-I Receptor human

General description
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase.[1] The gene is mapped to human chromosome 15q26.[2] It is expressed in various solid tumors as well as hematologic malignancies.[3] Application
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.[4] Biochem/physiol Actions
Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
Physical form
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
Analysis Note
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF­-­I in a functional ELISA assay