English
Application
Insulin solution from bovine pancreas has been used:
to study the effect of exogenous insulin on plasma concentrations of glucose, insulin, insulin-like growth factor I (IGF-I), and progesterone (P4) in pubertal beef heifers[1]
to study the insulin responsiveness of the placenta during pregnancy complications using primary human trophoblast cells and placental villous explants[2]
to study the effect of insulin receptor signaling dendritic spine density in neonatal mouse hippocampal neurons in vitro[3]
Biochem/physiol Actions
Insulin is a major glucose-lowering hormone, insufficiency of which causes hyperglycemia observed in type 2 diabetes.[4]
Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.
Physical form
stable 2-8 °C
