Macrophage Colony-Stimulating Factor human

General description
Macrophage Colony-Stimulating Factor (M-CSF) is a hematopoietic growth factor, which modulates the proliferation, differentiation and functional activation of monocytes.[1] It is produced by fibroblasts, endothelial cells and bone marrow stromal cells.[2] MCSF stimulates the functions of mature monocytes and macrophages.[1] Application
Macrophage Colony-Stimulating Factor human has been used for the differentiation of bone marrow-derived macrophages (BMDMs)[3] and human monocyte-derived macrophages (MDMs).[4] It has also been used for cell culture.[5] Biochem/physiol Actions
Macrophage colony-stimulating factor (M-CSF) augments many of the physiological functions of macrophages, and support osteoclast differentiation.
Physical form
Lyophilized from a sterile filtered buffered solution.
Analysis Note
The proliferative activity is tested in culture using the cytokine-dependent murine monocytic cell line M-NFS-60 cells.
Other Notes
159 amino acids including N-terminal methionine (each monomer).