Pilocarpine hydrochloride

Application
Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice.[1] It has also been used to induce status epilepticus(SE) in rat.[2][3] Biochem/physiol Actions
Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.
Pilocarpine is alkaloid isolated from the shrub Pilocarpus species. It comprises imidazole ring and γ- lactone rings in its structure. It has cholinergic potential and it stimulates the parasympathetic system. Pilocarpine is also effective for treating glaucoma.[4] It stimulates ciliary muscle contraction by binding to muscarinic M3 receptors.[5] It is effective in treating corneal dryness in Sjogren′s syndrome.[6] It is a secretagogue, which improves salivary secretions in Xerostomia or a dry mouth condition in Sjogren′s syndrome patients[7] and in radiotherapy patients with head and neck carcinoma.[8] Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes
Shelf life of the powder is at least five years.
Disclaimer
Hygroscopic, light sensitive