English
General description
Progesterone is a steroid hormone secreted by the ovaries.[1]
Application
Progesterone has been used:
as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture[2]
to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model[3]
as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells[4]
Use in cell culture applications to study sterol regulation of cell signaling and gene expression.
Biochem/physiol Actions
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy.[5] It is known to prevent preterm delivery, when administered intramuscularly.[6] Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.[7]
Physical form
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Preparation Note
To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.
Other Notes
Steroid hormone produced by the corpus luteum.
