English
General description
In humans, type I collagen is the most abundant and broadly expressed collagen. This heterotrimer contains two alpha 1 (I) chains and one alpha 2 (I) chain.[1] Collagen type I α 1 (COL1A1), a major component of collagen type I, codes for pro-α 1 chains of type I collagen.[2] It has repeating Gly-Xaa-Yaa tri-peptides motifs. The collagen alpha-1(I) chain protein is a member of the collagen complex superfamily.[1] COL1A1 has a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat, and a fibrillar collagen C-terminal domain (COLF).[2]
Application
Collagen Type I, rat tail has been used:
for collagen 3D proliferation assays[1]
for atelocollagen proliferation assays[1]
in a comparative study to make microcapsules for templating on mesoporous cores of pure vaterite calcium carbonate (CaCO3) crystals to evaluate the structure-property relationship[2]
in coverslip coating to grow the human cerebral microvascular endothelial cell line (hCMEC/D3) for creating a cell coculture and chronic subdural hematoma (CSDH) patient hematoma sample induced injury model[3]
Biochem/physiol Actions
Collagen type I α 1 (COL1A1) plays a key role in chemoresistance and may act as a therapeutic target. It is involved in carboplatin-resistant ovarian cancer (OV).[1] COL1A1 serves as an oncogene in the development of colorectal cancer (CRC).[2] Dominant inherited COL1A1 gene mutations result in connective tissue disorders such as osteogenesis imperfecta (OI).[1]
Physical form
0.02N acetic acid, pH 3.67
Preparation Note
1 year at 4°C
Analysis Note
Routinely evaluated by testing for uniform gelation and for attachment of and spreading of PC-12 rat cells
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
