Calcitonin human

Application
Calcitonin human has been used as a positive control in in vivo study of HLA-A(*) 02.01 (HHD) mice injected with PTH-rP peptides.[1] The product has also be used as a test compound for studying the effects of calcitonin deficiency and calcitonin substitution on particle-induced osteolysis in Calca -/- mice.[2] Calcitonin human has been used to study its ability to stimulate cAMP production post transfection in mammalian cell by activating human CALCRL (calcitonin receptor like receptor gene)- receptor activity-modifying protein 1 (RAMP1) and CTR (calcitonin receptor).[3] Biochem/physiol Actions
Hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes.
Calcitonin, also referred to as thyrocalcitonin, is a 32 amino acid peptide hormone, which is present abundantly in seminal plasma compared to serum. It acts as a first messenger and hence regulates the the production of cAMP as well as mammalian sperm function. It also facilitates the regulation of different isoforms of adenylyl cyclase.[4] Preparation Note
Calcitonin human dissolves in 1% acetic acid as well as in water at 1 mg/ml to yield a clear, colorless solution.
Other Notes
32 amino acid polypeptide, 8 of which are conserved across all species.
Lyophilized from 0.1% TFA in H2O