English
Application
E-4031 has been used as:
human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)[1]
IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies[2]
IKr blocker in rat ventricular myocytes[3]
Biochem/physiol Actions
E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation.[4] E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits.[5] An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.[6]
E-4031 selectively blocks hERG K+ channels.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
