Application
D-(+)-Galactosamine hydrochloride has been used to:
induce livery injury[1]
inflammatory liver injury[2]
acute liver failure (ALF)[3] in mice
Biochem/physiol Actions
Galactosamine (D-GalN) is synthesized from galactose and is potential hepatotoxic agent. D-GalN in combination with lipopolysaccharide leads to the development of lethal liver injury and hepatic failure.[4] It sensitizes cells to the toxic effects of the cytokine in particular the tumor necrosis factor(TNF).[5]

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