Fibroblast Growth Factor-Basic Heparin Stabilized human

General description
Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.[1] Application
Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV).[2] It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.[3] Biochem/physiol Actions
Fibroblast growth factor 2 (FGF2) participates in tissue development and repair.[1] It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system.[4] FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor.[1] bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types.[4] In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion.[5] It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.