English
General description
Chemical structure: glycopeptide
Vancomycin is a heptapeptide.[1]
Application
Vancomycin hydrochloride from Streptomyces orientalis has been used as:
an antibiotic in screening: minimal inhibitory concentrations (MICs) Streptomyces coelicolor[2]
in treating Leishmania infected sand flies[3]
in combined antibiotic treatment in asthma induced mice[4]
Biochem/physiol Actions
Mode of action: Inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides.
Antimicrobial Spectrum: Active against Gram-positive bacteria
Vancomycin is used for treating methicillin-resistant Staphylococcus aureus (MRSA) infections[1] and shunt-associated Staphylococcal ventriculitis.[5] It may lead to hypersensitivity reactions like anaphylaxis and red man syndrome.[6] Vanomycin is also used to treat thrombocytopenia[7] and induces drug reaction with eosinophilia and systemic symptoms (DRESS) on usage.[7]
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
